John Powderly II, MD, CPI
Dr. John Powderly grew up in Fairfax Virginia, and graduated from George Mason University in 1991 with a Bachelor of Science in Biology. He then attended Georgetown Medical School from 1991-95. Based on his academics and community involvement, he was awarded the Lawrence Dean Georgetown Scholarship. Most of his senior year at Georgetown was spent at the National Cancer Institute (NCI) as an intern at the Surgical Oncology Branch, Immunotherapy Division with Dr. Steve Rosenberg, focusing on melanoma immunotherapy.
He then attended the University of Texas, at the Houston Health Science Center, for a combined Medicine/Pediatrics Residency from 1995-99. In 1999-2000, he was appointed faculty at MD Anderson Cancer Center as an Attending Staff Internist, where he also performed additional melanoma immunotherapy research. His oncology fellowship at the University of North Carolina Chapel Hill from 2000-02 focused on dendritic cell immunotherapy.
Becoming triple board certified in Internal Medicine, Pediatrics, and Medical Oncology, he relocated to Charlotte, NC, the largest city in the nation without a medical school, and used this opportunity to build a community-based oncology research program. In 2003, he became Chairman of the Cancer Research Committee at Presbyterian Cancer Center and helped develop its network of clinical trials to become American College of Surgeons Commission on Cancer Accredited. He also became Section Chief of the Hematology/Oncology Division on the Medical Executive Committee Carolinas Medical Center (CMC) Mercy Hospital, and on the Executive Cancer Committee of CMC Charlotte.
Based on his community involvement in clinical trials, and hosting rotations for medical students and residents, he was appointed Adjunct Clinical Assistant Professor of Medicine at both Duke and UNC Chapel Hill. He helped develop the Certified Physician Investigator (CPI) curriculum for the Association of Clinical Research Professionals (ACRP). Dr. Powderly is also involved in community-based leadership initiatives by teaching immunotherapy educational sessions at American Society of Clinical Oncologists (ASCO) meetings, NC Oncology Society meetings, and Community Oncology Alliance (COA) national meetings.
In 2005, Dr. Powderly founded Carolina BioOncology Institute (CBI), a cancer therapy and research center that focuses on early phase immunotherapy trials. This community-based clinic in Huntersville, NC is the only independent, dedicated Phase I cancer center on the East Coast. CBI has opened more than 50 early phase clinical trials, has treated almost 3,000 cancer patients, and serves as a regional referral hub for Phase I access in the community setting.
Dr. Powderly’s research on early phase immunotherapy research has led to more than 40 publications, including articles in the New England Journal of Medicine, the Journal of Clinical Oncology, the Journal of Immunotherapy, Clinical Cancer Research, Clinical Chemistry, and Investigational New Drugs. Some of his articles and presentations have been recognized as “top 50 most cited articles by JCO” and “top 10 most downloaded ASCO Video Presentations.” He has also served as reviewer for multiple cancer journals, and served as a NIH grant reviewer.
As a strong advocate for clinical trial access in the community setting, Dr. Powderly has given many local newspaper, television and radio interviews, including an hour-long segment of “Charlotte Talks” on WFAE, the local NPR affiliate. Hosted by Mike Collins, the show focused on the low cancer clinical trial accrual rate in the U.S. Dr. Powderly has advocated for patient access to new cancer drugs to the FDA ODAC committee, and has appeared on CNBC national television interviews.
His entrepreneurial spirit and civic involvement helped form the Healthcare Industry Council of the Charlotte Chamber of Commerce. Dr. Powderly was recognized by the Charlotte Business Journal as one of the “Top 40 Under 40 Entrepreneurs Benefitting Charlotte”, and he has also been recognized at the Duke Power Centennial Economic Development Forum as “Innovator with Grand Designs Built Upon Collaboration.”
Dr. Powderly also founded BioCytics Inc., a Human Applications Lab that focuses on personalized medicine through molecular profiling of circulating tumor cells and cellular immunotherapy. In 2009, BioCytics received a $200,000 federal grant for its research, and now serves as a national reference lab for molecular profiling of circulating tumor cells on Phase I & II clinical trials.